Excerpt from "Negative Capability: Kerouac's Buddhist Ethic," by
The Four Noble Truths are as follows. First, existence contains suffering. Second, suffering is caused by ignorance of the conditions in which we exist—ignorance of the transitoriness and ignorance of anatma, the empty nature of the situation, so that everybody is afraid of a permanent condition of suffering and doesn't realize that suffering itself is transitory, impermanent. There is no permanent Hell, there is no permanent Heaven. Therefore, the suffering that we sense during this transition of life is not a permanent condition that we need to be afraid of. It's not where we're going to end up. We end liberated from the suffering either by death, or in life, by waking up to the nature of our situation and not clinging and grasping, screaming and being angry, resentful, irritable or insulted by our existence.
It is possible to take our existence as a "sacred world," to take this place as open space rather than claustrophobic dark void. It is possible to take a friendly relationship to our ego natures, it is possible to appreciate the aesthetic play of forms in emptiness, and to exist in this place like majestic kings of our own consciousness. But to do that, we would have to give up grasping to make everything come out the way we daydream it should.
So, suffering is caused by ignorance, or suffering exaggerated by ignorance or ignorant grasping and clinging to our notion of what we think should be, is what causes the "suffering of suffering." The suffering itself is not so bad, it's the resentment against suffering that is the real pain. This is where I think Kerouac got caught as a Catholic, ultimately, because I don't think he overcame that fear of the First Noble Truth.